Estimation of Recombinant Faction

Product Method

Example I

Example II - Interpolation

Development Of The Product Method

Repulsion Linkage

Example III

Combined Estimates Using the Product Method

  Click here for a
printer-friendly version

Repulsion Linkage

   p 
2
  AB  

1- p
2
  Ab  

1 - p
2
  aB  

 p 
2
  ab  

 p 
2
AB
(p/2)2
AABB
AABb AaBB AaBb
1- p
2
Ab
AABb AAbb AaBb Aabb
1 - p
2
aB
AaBB AaBb aaBB aaBb
 p 
2
ab
AaBb Aabb aaBb (p/2)2
aabb

We can collect the relative proportion of each of the four classes of phenotypes and develop the following table:

Type Proportion
Expected
Observed
Designation
A_B_ 4 - 2(1- p2) - p2 = 2 + p2
            4                4
r
A_bb (1 - p)2 + p(1 - p) + p(1 - p) = 1 - p2
                       4                     4
s
aaB_ (1 - p)2 + p(1 - p) +p(1 - p) = 1 - p2
                  4                         4
t
aabb p2 = p2
4      4
u

Now for repulsion linkage, s and t are the observed numbers of parental classes. The recombinant (non-parental) classes are u and part of the r class. With closer linkage the r and u classes should decrease, while the s and t classes will increase. The ratio ru/st is a measure of linkage in repulsion.

Copyright 2000©, Ted Helms

Back | Home | Top | Next
Home Forward Back