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Homework Assignment #8
Questions
| 1. |
You have read in a Theoretical and Applied Genetics
manuscript that the authors reported a 100cM distance
between two loci.
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| a) |
Find 'p' which is the observed recombination
fraction between the two loci based on
two-point linkage analysis. |
| b) |
Explain why the estimate of p does not equal
the distance in centiMorgans. |
| 2. |
You are planning an experiment to determine whether
the segregation of two unlinked loci which determine
the phenotype of a trait fits a 9:7 ratio or a 13:3 ratio. |
| a) |
What is the minimum number of F2 progeny that
must be grown to distinguish between the two
ratios when the probability of Type I error is
set at 0.05? |
| b) |
What is the critical number of dominant
phenotypes that are necessary to distinguish
between these two ratios when a = 0.05? |
| 3. |
A trait is determined by two loci located on
non-homologous chromosomes. You want to determine
whether a parental plant is homozygous dominant
(AABB) or doubly heterozygous (AaBb). The parental
plant is self-fertilized to produce the F2 generation.
The expected F2 ratio of an AaBb plant is 15 purple
flowered plants: 1 white flowered plant. How many
F2 plants must be grown to determine correctly in 99
out of 100 trials whether the parent plant is doubly
heterozygous? |
| 4. |
Plot the information content, as the recombination
fraction (p) is varied, for two loci in coupling phases
linkage using F2 data. |
Copyright
2000©, Ted Helms
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