An Example
r estimated from observed recombination = 0.30.
r = 1/2(1 - e-2d)
= 0.30
1 - e-2d
= 0.60
0.4 = e-2d
ln(0.4) =-2d
-ln(0.4) = 2d
-(-0.916) = 2d
d = 0.458
l is the mean number of crossover events.
Each crossover results in 50% recombination. Then l/2
= m.
m = recombination fraction
** The observed recombination percent was 0.3, the actual relative
frequency of recombinant types is 0.458. The adjusted recombination
percent is multiplied by two to equal the crossover percent. This is
because each crossover event results in 50% non-parental gametes. The
map is 45.8cM.
Haldane's mapping function converts the relationship
of the sum of two intervals to the sum of the total
interval into a linear relationship.
rAC
does not equal rAB
+ rBC
dAC
= dAB
+ dBC
pg 20. Liu, B.H. Statistical Genomics.
